Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands. Academic Article uri icon

abstract

  • New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.

published proceedings

  • Bioorg Med Chem Lett

altmetric score

  • 12

author list (cited authors)

  • Gao, M., Kong, D., Clearfield, A., & Zheng, Q.

citation count

  • 48

complete list of authors

  • Gao, Mingzhang||Kong, Deyuan||Clearfield, Abraham||Zheng, Qi-Huang

publication date

  • April 2006