Synthesis of Carbon-11 Labeled Triphenylacetamides as Novel Potential PET Melanoma Cancer Imaging Agents
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New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported. © Georg Thieme Verlag Stuttgart.
author list (cited authors)
Gao, M., Kong, D., Clearfield, A., Miller, K., Sledge, G., & Zheng, Q.