Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents Academic Article

abstract

• New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported. Georg Thieme Verlag Stuttgart.

authors

• Clearfield, Abraham

published proceedings

• SYNTHESIS-STUTTGART

altmetric score

• 3

author list (cited authors)

• Gao, M., Kong, D., Clearfield, A., Miller, K. D., Sledge, G. W., & Zheng, Q.

citation count

• 1

complete list of authors

• Gao, Mingzhang||Kong, Deyuan||Clearfield, Abraham||Miller, Kathy D||Sledge, George W||Zheng, Qi-Huang

publication date

• July 2006

publisher

• Thieme  Publisher

published in

• Synthesis  Journal

keywords

• 3-phenyl-(r)-2-(2,2,2-triphenylacetylamino)propionic Acid [c-11]methyl Ester
• Imaging Agents
• Melanoma Cancer
• N-(4-[c-11]methoxyphenyl)-2,2,2-triphenylacetamide
• Positron Emission Tomography
• Triphenylacetamides

Digital Object Identifier (DOI)

• 10.1055/s-2006-942442

start page

• 2301

end page

• 2304

volume

• 2006

issue

• 14

URL

• http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-2006-942442