Efficient estimation of the distribution of quality-adjusted survival time. Academic Article

abstract

• Quality of life is an important aspect in evaluation of clinical trials of chronic diseases, such as cancer and AIDS. Quality-adjusted survival analysis is a method that combines both the quantity and quality of a patient's life into one single measure. In this paper, we discuss the efficiency of weighted estimators for the distribution of quality-adjusted survival time. Using the general representation theorem for missing data processes, we are able to derive an estimator that is more efficient than the one proposed in Zhao and Tsiatis (1997, Biometrika 84, 339-348). Simulation experiments are conducted to assess the small sample properties of this estimator and to compare it with the semiparametric efficiency bound. The value of this estimator is demonstrated from an application of the method to a data set obtained from a breast cancer clinical trial.

authors

• Zhao, Hongwei

published proceedings

• Biometrics

author list (cited authors)

• Zhao, H., & Tsiatis, A. A.

citation count

• 51

complete list of authors

• Zhao, H||Tsiatis, AA

publication date

• December 1999

publisher

• Wiley  Publisher

published in

• Biometrics  Journal

keywords

• Biometry
• Breast Neoplasms
• Clinical Trials As Topic
• Computer Simulation
• Female
• Humans
• Models, Statistical
• Quality-adjusted Life Years
• Survival Analysis

PubMed Central ID

• 11315054

Digital Object Identifier (DOI)

• 10.1111/j.0006-341x.1999.01101.x

start page

• 1101

end page

• 1107

volume

• 55

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1111%2Fj.0006-341x.1999.01101.x