A consistent estimator for the distribution of quality adjusted survival time
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abstract
Quality adjusted survival analysis is a new approach to therapy evaluation in clinical trials. It has received much attention recently because of its ability to take patients' quality of life into consideration. In this paper, we present a method that enables us to calculate the survival distribution of quality adjusted lifetime. Using martingale theory for counting processes, we can show that our estimator is asymptotically consistent, normally distributed, and its asymptotic variance estimate can be obtained analytically. Simulation experiments are conducted to compare our estimator with the true underlying distribution for two cases that are of practical importance.
