Mohan, Anand (2005-08). Modeling the growth and dissolution of clots in flowing blood. Doctoral Dissertation. Thesis uri icon

abstract

  • Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. The broad stimuli for clot formation were laid out, more than a century ago, in, what is now referred to as, Virchow??????s triad. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical and rheological factors, has not been put into place, the existing models emphasizing either one or the other of the factors. In this dissertation, a model is developed for clot formation and dissolution that incorporates many of the relevant crucial factors that have a bearing on the problem. The model, though just a first step towards understanding a complex phenomenon goes further than previous models in integrating the biochemical, medical and rheological factors that come into play. The model is tested in some simple flow situations as part of an attempt to elucidate Virchow??????s triad. Extensions to the model, along with detailed numerical studies, will hopefully aid in a clearer understanding of the phenomenon, and in making relevant clinical correlations.
  • Multiple interacting mechanisms control the formation and dissolution of clots to
    maintain blood in a state of delicate balance. In addition to a myriad of biochemical
    reactions, rheological factors also play a crucial role in modulating the response of
    blood to external stimuli. The broad stimuli for clot formation were laid out, more
    than a century ago, in, what is now referred to as, Virchow??????s triad. To date, a
    comprehensive model for clot formation and dissolution, that takes into account the
    biochemical, medical and rheological factors, has not been put into place, the existing
    models emphasizing either one or the other of the factors. In this dissertation, a model
    is developed for clot formation and dissolution that incorporates many of the relevant
    crucial factors that have a bearing on the problem. The model, though just a first step
    towards understanding a complex phenomenon goes further than previous models in
    integrating the biochemical, medical and rheological factors that come into play. The
    model is tested in some simple flow situations as part of an attempt to elucidate
    Virchow??????s triad. Extensions to the model, along with detailed numerical studies, will
    hopefully aid in a clearer understanding of the phenomenon, and in making relevant
    clinical correlations.

publication date

  • August 2005