High-throughput Screening and Detection of Circulating Tumor Cells
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abstract
The technologies proposed here offer potential to deliver a transformative advance in cancer diagnostics and treatment by enabling rapid (~ 40 min) analysis and characterization of the entire cell population in a 1 mL blood sample. Unlike current methods based on antibody capture and fluorescent labeling, our approach eliminates the need for staining and permits all cells to be simultaneously probed, delivering at least a 10-fold reduction in analysis time, while simultaneously providing a wealth of currently unavailable morphological information across the entire cell population that can be mined to gain new diagnostically relevant insights. The goal of this proposal is to overcome remaini... Read More The technologies proposed here offer potential to deliver a transformative advance in cancer diagnostics and treatment by enabling rapid (~ 40 min) analysis and characterization of the entire cell population in a 1 mL blood sample. Unlike current methods based on antibody capture and fluorescent labeling, our approach eliminates the need for staining and permits all cells to be simultaneously probed, delivering at least a 10-fold reduction in analysis time, while simultaneously providing a wealth of currently unavailable morphological information across the entire cell population that can be mined to gain new diagnostically relevant insights.........
