Journal of Pharmacology and Experimental Therapeutics
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Overview
publication venue for
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Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents..
388:260-267.
2024
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Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats-Editorial..
388:257-259.
2024
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Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents (Special Issue on Medical Countermeasures -Commentary)..
JPET-COM-2023-002040.
2024
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Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation..
jpet-ar-2023-001819.
2023
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Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations and Electrographic Ictal Biomarkers..
jpet-ar-2023-001817.
2023
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A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-term Epileptic Seizure Activity, Neurological Dysfunction and Neurodegeneration..
jpet-ar-2023-001794.
2023
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Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic..
jpet-mr-2023-001816.
2023
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Long-term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids..
JPET-AR-2023-001763.
2023
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Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage..
JPET-AR-2023-001747.
2023
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Therapeutic Basis of Generic Substitution of Antiseizure Medications..
381:188-196.
2022
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The Cannabinoid Receptor Type 1 Positive Allosteric Modulator ZCZ011 Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice..
380:1-14.
2022
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Inhibiting Sialidase-Induced TGF-1 Activation Attenuates Pulmonary Fibrosis in Mice..
376:106-117.
2021
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Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam..
372:285-298.
2020
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Correction to "Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease"..
369:66-66.
2019
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Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents..
367:302-321.
2018
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NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis..
366:46-57.
2018
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3-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic -Subunit -Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield..
365:583-601.
2018
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The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism..
365:636-651.
2018
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Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy..
364:180-197.
2018
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Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy..
364:97-109.
2018
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Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice..
361:17-28.
2017
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Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice..
358:50-60.
2016
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Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic GABA(A) Receptors..
357:188-204.
2016
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The Pharmacological Basis of Cannabis Therapy for Epilepsy..
357:45-55.
2016
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Antiseizure Activity of Midazolam in Mice Lacking -Subunit Extrasynaptic GABA(A) Receptors..
353:517-528.
2015
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Estrous cycle regulation of extrasynaptic -containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis..
346:146-160.
2013
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Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease..
345:125-138.
2013
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Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels..
345:7-14.
2013
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Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells..
343:333-341.
2012
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Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice..
343:401-412.
2012
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A mouse kindling model of perimenstrual catamenial epilepsy..
341:784-793.
2012
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ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models..
338:134-142.
2011
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Protein kinase CbetaII-mediated phosphorylation of endothelial nitric oxide synthase threonine 495 mediates the endothelial dysfunction induced by FK506 (tacrolimus)..
337:718-723.
2011
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Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor..
335:172-179.
2010
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The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors..
334:1031-1041.
2010
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Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice..
318:629-640.
2006
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Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells..
313:855-861.
2005
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Estrogen regulation of the cytochrome P450 3A subfamily in humans..
311:728-735.
2004
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Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice..
310:230-239.
2004
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Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates..
305:394-401.
2003
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Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis..
303:904-908.
2002
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Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition..
301:1132-1138.
2002
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Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself..
295:1241-1248.
2000
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Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma..
295:677-681.
2000
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Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy..
294:909-915.
2000
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Allopurinol prevents early alcohol-induced liver injury in rats..
293:296-303.
2000
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Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels..
291:655-664.
1999
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Determinants of channel gating located in the N-terminal extracellular domain of nicotinic alpha7 receptor..
287:469-479.
1998
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Glycine accelerates recovery from alcohol-induced liver injury..
286:1014-1019.
1998
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Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor..
283:876-884.
1997
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L-glutamine inhibits nitric oxide synthesis in bovine venular endothelial cells..
281:448-453.
1997
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Testosterone causes direct relaxation of rat thoracic aorta..
277:34-39.
1996
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Comparison of 4-aminopyridine and tetrahydroaminoacridine on basal forebrain neurons..
255:986-993.
1990
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Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists..
252:474-481.
1990
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Angiotensin II vascular receptors in fowl aorta: binding specificity and modulation by divalent cations and guanine nucleotides..
251:1076-1082.
1989
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Phenytoin reduces excitatory synaptic transmission and post-tetanic potentiation in the in vitro hippocampus..
246:851-858.
1988
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Effects of fenoldopam on feline intestinal microcirculation..
244:983-986.
1988
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Inhibition of guinea pig ileum contractions mediated by a class of histamine receptor resembling the H3 subtype..
243:874-880.
1987
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Denervation-induced supersensitivity to calcium of chemically skinned smooth muscle of the guinea-pig vas deferens..
236:80-84.
1986
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Reduction of ventricular fibrillation threshold by histamine: resolution into separate H1- and H2-mediated components..
223:774-783.
1982
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Effects of barbiturates and ethanol on the physical properties of brain membranes..
223:424-431.
1982
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The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist..
214:629-634.
1980
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Ouabain increases left atrial stretch receptor discharge in the dog..
212:320-324.
1980
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Effects of patulin on the kinetics of substrate and cationic ligand activation of adenosine triphosphatase in mouse brain..
205:606-616.
1978
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Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps..
359:110-123.
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Acid Sphingomyelinase Inhibitor Protects Against the Nicotine-Induced Podocyte Injury
Identity
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